ABSTRACT
Background: Both healthcare personnel and patients have been impacted negatively by the COVID-19 epidemic, which has had a substantial effect on the healthcare sector. The healthcare workforce consists of physicians, nurses, and other healthcare professionals. Objective(s): To assess the psychological impact of COVID19 pandemic among different healthcare providers by assessing the depression, stress level, and anxiety related to COVID19 pandemic and the effect it had on their practice and psychological well-being. Methodology: To learn more about the experiences of healthcare professionals and to ascertain the effects of COVID-19 on their practice, a cross-sectional observational study including 311 practicing physicians, pharmacists, nurses, dentists, lab technicians, and other hospital staff members was carried out across Saudi Arabia. A pretested semi-structured QuestionPro questionnaire that was sent electronically via social media, email, and phones was used to collect responses from study participants. It was cleaned up before being examined with SPSS program 28. Frequency and percentage displays were used to illustrate quantitative data. Spearman's correlation was used to calculate the association between stress score, anxiety score, and depression score. Appropriate statistical tests of significance were used to determine the association between stress scores and various background characteristics. Statistical significance was set at the 0.05 level for P-value. Result(s): Over half of the medical staff had expertise in caring for COVID-19 patients, and approximately two out of every five trial participants had a history of COVID-19 infection previous to immunisation. The vaccine could minimise the infection, according to 3/4 of them. Among those surveyed, just 33% had a history of chronic diseases. The majority of participants believed they had dealt with difficult events at some time in the preceding week for all of the categories. Similar to this, depression was sometimes experienced for 4 items but never for 3 when there were the most participants. It could be deduced that the majority of participants had normal Anxiety (33.8%), Stress (36%), and Depression (38.6%) scores. The median psychological assessments were considerably higher among those who were between the ages of 35 and 56, divorced, were already infected with the COVID-19 virus previous to immunisation, and had a history of chronic disease. Conclusion(s): The study's findings led to the conclusion that stress and anxiety are significant COVID-19 effects on both healthcare professionals and patients. The epidemic has also highlighted the significance of the need for appropriate safety equipment, practices, and support for the physical and mental well-being of medical personnel.Copyright © 2023, Codon Publications. All rights reserved.
ABSTRACT
Objective: This present study seeks to summarise the psychological impact of COVID-19, address the mental health outcomes during a pandemic, and conduct a meta-analysis to draw conclusions and recommend coping strategies. Methodology: We follow the Preferred Reporting Items guideline for conducting this systematic review analysis (PRISMA). Online resources like PUBMED, ProQuest" and the "Web of Science" database were assessed to assemble the relevant research. A correlation model fixed effect model was used to generate proportions with 95 % confidence intervals (CI) and model fitted weights. Cochrane Q test and I2 tests were performed for measuring heterogeneity. Egger regression asymmetry test and funnel plot were to measure the publication bias. Result(s): Total of 12 articles were included with the main parameters of depression, anxiety, and stress. Out of these 12 articles eight (66.6%), articles were cross-sectional while four (33.3%) were online surveys. Meta-analysis shows 99.4% significant heterogeneity. Eggers test shows the 0.5726 value which indicates that no publication bias was reported. Conclusion(s): The prevalence of depression and anxiety among healthcare professionals was elevated during a pandemic. Female workers especially nurses working in COVID wards show more depression than others due to the unfavourable condition of patients.Copyright © 2022, Universidade de Sao Paulo. Museu de Zoologia. All rights reserved.
ABSTRACT
Our retrospective study aimed to evaluate the effectiveness of monoclonal antibodies (casirivimab and imdevimab) on mild cases of coronavirus disease 2019 patients admitted to the tertiary care center. A total of 161 patients were evaluated of which the test group consisted of 79 and the control group of 82. In the test group the patients had been administered with diluted 250 ml of 0.9 % sodium chloride along with co-formulated casirivimab (600 mg) and imdevimab (600 mg) solution intravenously and in the control group the patients were administered standard coronavirus disease 2019 treatment protocol. The monitoring of patients in both groups was done at least 1 h after drug infusion in the designated room. Post-treatment designed interviews were taken to evaluate the effectiveness of treatment. This retrospective analysis discovered a significant association of symptoms with the group at 48 h for injected and non-injected patients and 1 mo from the chi-square test after injecting monoclonal antibodies. There is no significant association of symptoms with the groups at 3 mo. A significant difference in the symptom distribution through different time points in the injected group and not injected group was observed. From the pairwise McNemar's test, a significant difference in the symptoms between each time in 48 h, the difference was p=0.0075 and after 1 mo, p<0.001 points in both groups. The combination of casirivimab and imdevimab could be considered a treatment of choice for vaccinated, non-vaccinated and mild to highrisk coronavirus disease 2019 patients.